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After several years of trying to figure out what task manager for Mac and iPhone worked best with my peculiar style of organization, I finally settled on Things from Cultured Code. The Mac application is easy to use, uncluttered, and can take advantage of many keyboard shortcuts, while the iPhone app [iTunes Link] gives me a portable version of the Things database to take on the road. While the iPhone app can do a local sync to a Mac, it still doesn't do over-the-air syncing, which I hope Cultured Code will add in a future release.
When I made Things my task manager, I needed to make sure that I could use the same database on both my desktop Mac and my MacBook Air, since the Mac version doesn't do syncing either. It turns out that one of the easiest ways to do this is to use the wonderful cloud storage application Dropbox to hold my Things database, and then point Things on both Macs to use the shared database.